Gene expression change database

Download page for up- or down-regulated gene list is here (CSV files for each compoud can be downloaded.)

The number of up- and down-regulated gene signatures for 99 anticancer compounds (129 treatment samples)
IDCompoundcelltimeup
x3(x2)
down
x3(x2)
C001 2-Deoxyglucose HT29 6hrs 130(586) 16(439)
C002 Tunicamycin HT29 6hrs 209(768) 63(673)
C003 Thapsigargin HT29 6hrs 69(323) 3(119)
C004 A23187 HT29 6hrs 266(986) 86(931)
C005 Cisplatin HT29 6hrs 19(256) 52(697)
C006 Trichostatin A HT29 6hrs 232(1427) 181(1238)
C007 Vorinostat HT29 6hrs 233(1389) 173(1245)
C008 Bortezomib HT29 6hrs 94(494) 68(659)
C009 MG-132 HT29 6hrs 63(428) 51(583)
C010 Geldanamycin HT29 6hrs 0(29) 0(32)
C011 17-AAG HT29 6hrs 7(68) 0(41)
C012 Vincristine HT29 6hrs 0(45) 0(6)
C013 Paclitaxel HT29 6hrs 0(41) 0(9)
C014 Docetaxel HT29 6hrs 1(37) 0(8)
C015 5-FU HT29 6hrs 3(131) 14(154)
C016 Gemicitabine HT29 6hrs 2(26) 5(49)
C017 Melphalan HT29 6hrs 85(716) 242(1553)
C018 Mitomycin C HT29 6hrs 3(69) 9(252)
C019 Oxaliplatin HT29 6hrs 0(11) 9(81)
C020 Bleomycin HT29 6hrs 0(6) 1(5)
C021 Actinomycin D HT29 6hrs 26(294) 188(1384)
C022 Neocarzinostatin HT29 6hrs 0(57) 2(138)
C023 Methotrexate HT29 6hrs 1(28) 8(62)
C024 6-Mercaptopurine HT29 6hrs 2(38) 2(52)
C025 Temsirolimus HT29 6hrs 10(132) 0(24)
C026 Everolimus HT29 6hrs 16(162) 0(13)
C027 PP242 HT29 6hrs 98(788) 37(530)
C028 Nimustine HT29 6hrs 7(131) 13(318)
C029 SN-38 HT29 6hrs 75(602) 512(2445)
C030 Camptothecin HT29 6hrs 102(735) 809(3151)
C031 Topotecan HT29 6hrs 28(576) 190(1268)
C032 Doxorubicin HT29 6hrs 49(459) 184(1323)
C033 Etoposide HT29 6hrs 2(41) 7(133)
C034 Mitoxantrone HT29 6hrs 47(312) 179(1408)
C035 Pemetrexed HT29 6hrs 2(16) 5(34)
C036 Sorafenib HT29 6hrs 50(345) 10(225)
C037 Sorafenib HT29 6hrs 29(163) 8(116)
C038 Sunitinib HT29 6hrs 17(186) 6(118)
C039 Sunitinib HT29 6hrs 14(121) 3(67)
C040 Lapatinib3 HT29 6hrs 0(1) 0(12)
C041 Lapatinib10 HT29 6hrs 4(51) 1(16)
C042 Dasatinib HT29 6hrs 0(7) 0(15)
C043 Erlotinib HT29 6hrs 15(80) 1(30)
C044 Gefitinib10 HT29 6hrs 9(40) 1(31)
C045 Gefitinib30 HT29 6hrs 23(220) 3(99)
C046 Pazopanib HT29 6hrs 28(298) 36(429)
C047 Vorinostat HT29 16hrs 434(2142) 478(2057)
C048 Bortezomib HT29 16hrs 268(1379) 299(1882)
C049 Geldanamycin HT29 16hrs 0(6) 0(2)
C050 17-AAG HT29 16hrs 0(9) 1(8)
C051 Vincristine HT29 16hrs 28(293) 77(335)
C052 Paclitaxel HT29 16hrs 21(263) 60(281)
C053 Docetaxel HT29 16hrs 18(221) 57(270)
C054 5-FU HT29 16hrs 26(543) 39(556)
C055 Mitomycin C HT29 16hrs 25(404) 57(605)
C056 Vorinostat HT29 6hrs 297(1543) 229(1444)
C057 Bortezomib HT29 6hrs 118(596) 97(904)
C058 Vorinostat HT29 16hrs 462(2266) 465(2106)
C059 Bortezomib HT29 16hrs 307(1551) 373(1893)
C060 Gemicitabine HT29 16hrs 15(339) 8(186)
C061 Oxaliplatin HT29 16hrs 7(167) 53(410)
C062 Bleomycin HT29 16hrs 3(23) 7(29)
C063 Neocarzinostatin HT29 16hrs 13(255) 9(180)
C064 Methotrexate HT29 16hrs 67(692) 53(507)
C065 6-Mercaptopurine HT29 16hrs 35(388) 9(273)
C066 Temsirolimus HT29 16hrs 1(81) 1(27)
C067 Everolimus HT29 16hrs 0(64) 0(31)
C068 PP242 HT29 16hrs 192(1206) 106(924)
C069 Etoposide HT29 16hrs 33(456) 31(405)
C070 Pemetrexed HT29 16hrs 24(400) 8(186)
C071 Amrubicin HT29 6hrs 38(285) 29(320)
C072 MLN-4924 HT29 6hrs 25(166) 16(208)
C073 Akt Inhibitor VIII HT29 6hrs 77(532) 9(306)
C074 ATM/ATR kinase inhibitor HT29 6hrs 46(316) 4(177)
C075 Cdk4 inhibitor HT29 6hrs 78(451) 6(212)
C076 SB218078 HT29 6hrs 27(305) 36(642)
C077 Chk2 inhibitor II HT29 6hrs 313(1029) 181(1403)
C078 GSK-3 inhibitor IX HT29 6hrs 14(135) 11(209)
C079 5-Aza-2'-deoxycytidine HT29 6hrs 11(62) 0(14)
C080 FH535 HT29 6hrs 47(250) 8(122)
C081 BI 2536 HT29 6hrs 1(25) 2(21)
C082 Aurora kinase inhibitor III HT29 6hrs 1(50) 3(12)
C083 NU6102 HT29 6hrs 111(570) 218(1609)
C084 TX-1918 HT29 6hrs 35(153) 0(22)
C085 AG1024 HT29 6hrs 79(425) 13(302)
C086 U-0126 HT29 6hrs 57(429) 52(415)
C087 SU11274 HT29 6hrs 5(127) 2(76)
C088 PDGF inhibitor V HT29 6hrs 4(63) 3(60)
C089 PKR inhibitor HT29 6hrs 48(471) 754(3066)
C090 Decitabine HT29 6hrs 0(10) 0(21)
C091 Romidepsin HT29 6hrs 4(121) 2(54)
C092 Vandetanib HT29 6hrs 31(223) 2(94)
C093 Vemurafenib HT29 6hrs 81(578) 84(585)
C094 Crizotinib HT29 6hrs 258(1078) 219(1730)
C095 Ruxolitinib HT29 6hrs 92(934) 882(3307)
C096 Axitinib HT29 6hrs 50(195) 31(377)
C097 Vismodegib HT29 6hrs 9(99) 2(70)
C098 Carfilzomib HT29 6hrs 19(123) 8(188)
C099 Regorafenib HT29 6hrs 60(484) 60(469)
C100 Cabozantinib HT29 6hrs 116(700) 110(751)
C101 SN-38 Skov3 6hrs 145(747) 186(1800)
C102 Doxorubicin Skov3 6hrs 5(325) 418(2393)
C103 Lapatinib Skov3 6hrs 4(79) 4(60)
C104 SN-38 K562 6hrs 137(1088) 383(1943)
C105 Doxorubicin K562 6hrs 6(173) 9(209)
C106 Imatinib K562 6hrs 37(321) 24(256)
C107 Bosutinib K562 6hrs 35(379) 29(331)
C108 Dasatinib K562 6hrs 32(312) 22(228)
C109 Nilotinib K562 6hrs 19(216) 23(244)
C110 Ponatinib K562 6hrs 35(329) 37(331)
C111 SN-38 PC9 6hrs 99(471) 320(1854)
C112 Doxorubicin PC9 6hrs 2(104) 4(173)
C113 Erlotinib0.6 PC9 6hrs 22(184) 28(210)
C114 Erlotinib30 PC9 6hrs 42(286) 27(279)
C115 Gefitinib0.6 PC9 6hrs 20(190) 22(201)
C116 Gefitinib30 PC9 6hrs 37(272) 15(206)
C117 Alectinib/CH5424802 HT29 6hrs 15(164) 1(28)
C118 Celecoxib HT29 6hrs 334(1376) 145(1228)
C119 BKM120 HT29 6hrs 45(408) 4(128)
C120 BEZ235 HT29 6hrs 67(473) 13(280)
C121 Dabrafenib HT29 6hrs 18(150) 33(243)
C122 Trametinib HT29 6hrs 1(35) 1(28)
C123 Afatinib HT29 6hrs 29(193) 2(81)
C124 Afatinib PC9 6hrs 13(150) 22(197)
C125 Trametinib PC9 6hrs 10(79) 22(136)
C126 Crizotinib H2228 6hrs 44(322) 8(297)
C127 CH5424802 H2228 6hrs 101(482) 1(80)
C128 SN38 H2228 6hrs 74(257) 230(1473)
C129 Doxorubicin H2228 6hrs 2(31) 385(1812)